Activated NK cells expressing γ-interferon (IFN-γ) and TNF-α contribute further to the activation of macrophages, DCs, and T cells, amplifying the immune response [8, 20], which are recruited to the site of virus-infected tumors, and altering the cytokine environment and the immune cells in the TME, thereby overcoming tumor-associated immunosuppression [25]. This evidence concerns the gene IFNG and neoplasm.