For one, phagocytosis and antigen presentation by macrophages synergize with OVs to inhibit tumor growth, while OVs also stimulate the shift of macrophages to an antitumor phenotype; as for another, macrophages in turn mediate the clearance of OVs through the secretion of interferon type I (IFN) and the phagocytosis of OVs particles, a role that is an important factor in limiting the systemic administration of OVs [13, 14]. Here, IFNA1 is linked to neoplasm.