Among Pattern Recognition Receptors (PRRs), Toll-like receptors(TLRs) (such as TLR3,8 and 7) and Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) including RIG-I and MAD-5 recognize the virus genetic material (ss RNA or ds RNA) in the initial phase of infection and lead to stimulation of INFs (Interferons) signaling pathway [3, 4]. The gene discussed is RIGI; the disease is infection.