Similar to activated B cells, SLE patients with active disease (SLEDAI-2k ≥ 6 with a clinical SLEDAI-2k (excluding laboratory results) score ≥ 4) showed decreased Mcl-1 expression in both CD4+/CD8+ T cell populations after activation (Fig. 5E–F). The gene discussed is CD8A; the disease is systemic lupus erythematosus.