To further explore the effects of NRCAM on HCC and metastasis in vivo, MIG-Vec, MIG-MYC, MIG-MYC-shNrcam, and MIG-MYC-NRCAM organoids were transplanted through intrahepatic injection into C57BL/6 mice with transient irradiation induced immunodeficiency (Fig. S5A-C). This evidence concerns the gene NRCAM and immunodeficiency disease.