ADAMTS13 and thrombotic thrombocytopenic purpura: The primary conditions associated with TMA are linked to two main causes: ADAMTS13 deficiency, leading to Thrombotic Thrombocytopenic Purpura (TTP), and complement dysregulation, leading to complement-mediated TMA (CM-TMA), also named atypical Hemolytic Uremic Syndrome (aHUS) [5].