It is, however, paradoxical that the expression of TRIM21 mRNA and protein in SLE and pSS populations is found to be higher than that in healthy controls, and this increased level of TRIM21 could result in increased cell death and enhanced autogenic antigen exposure with subsequent antigen stimulation of autoimmune B cells, thus serving as a connection with the development of lymphoma [105] (Fig. 2). Here, TRIM21 is linked to systemic lupus erythematosus.