Since it is demonstrated that there is higher TRIM21 expression among individuals with SLE or pSS and that several studies confirmed that overexpression of TRIM21 is associated with the inhibition of breast cancer development and a better prognosis for those individuals who develop breast cancer, it is worth further investigation of the TRIM21 expression level in SLE and pSS patients in these Asian countries. This evidence concerns the gene TRIM21 and breast carcinoma.