A study by Gu et al., which examined the underlying mechanism of how FASN promotes lipogenesis and HCC progression, found that the acetylation of glyceronephosphate O-acyltransferase (GNPAT), a critical enzyme that regulates plasmalogens, stabilizes FASN via suppressing both TRIM21/Ro52-mediated GNPAT and FASN degradation [111]. This evidence concerns the gene TRIM21 and hepatocellular carcinoma.