The gene that encodes A20, or TNF alpha-induced protein 3 (TNFAIP3), an immunoregulatory factor involved in the downregulation of the NF-κB pathway and the carcinogenesis of lymphoma and solid tumors, often includes a single-nucleotide polymorphism and one gene mutation in SLE patients that are absent in healthy individuals [93]. This evidence concerns the gene TNFAIP3 and lymphoma.