In contrast, it is shown in CRC that TRIM21/Ro52 mediates the ubiquitination of MICAL-like 2 protein (MICALL2), which is proven to promote CRC cell proliferation and migration, and thereby the presence of TRIM21/Ro52 decrease the activity of MICALL2 in CRC tumorigenesis [52]. The gene discussed is MICALL2; the disease is colorectal carcinoma.