It was also observed in colorectal and pancreatic tumor cells that TRIM21/Ro52 overexpression in response to cisplatin, a widely used chemotherapeutic agent, would downregulate the level of pro-apoptotic WT1 regulator (PAWR), which is a tumor suppressor mediating apoptosis regulation in various cancer cells, and thus increases the resistance of colorectal and pancreatic tumor cells to cisplatin treatment. This evidence concerns the gene WT1 and pancreatic neoplasm.