TRIM21 and metastatic malignant neoplasm in the lymph nodes: TRIM21/Ro52 plays a similar role in thyroid cancer, such that the expression of TRIM21/Ro52 is upregulated in thyroid cancer tissue, and higher TRIM21/Ro52 levels are associated with a higher risk of recurrence and lymph node metastasis, though the mechanism involved has not yet been investigated [16].