A study also showed that the presence and elevated serum level of anti-TRIM21/Ro52 in SLE and pSS patients are positively correlated with the abnormally increased titer of immunoregulatory cytokine, including IL-2, IL-4, IL-21, IL-22, and CXCL10 [35]. Here, TRIM21 is linked to systemic lupus erythematosus.