It was also observed in colorectal and pancreatic tumor cells that TRIM21/Ro52 overexpression in response to cisplatin, a widely used chemotherapeutic agent, would downregulate the level of pro-apoptotic WT1 regulator (PAWR), which is a tumor suppressor mediating apoptosis regulation in various cancer cells, and thus increases the resistance of colorectal and pancreatic tumor cells to cisplatin treatment. Here, TRIM21 is linked to cancer.