In pSS patients, higher serum level of anti-TRIM21/Ro52 antibodies are associated with increased disease severity, including a greater rate of anemia and muscular involvement, despite no clear association between the presence of anti-TRIM21/Ro52 antibodies and xerostomia, one of the most notable clinical presentation found on pSS patients [37]. Here, TRIM21 is linked to anemia (phenotype).