Interestingly, recent studies show that hnRNPU-derived hsa_circ_0017272 is able to encode a protein consisting of 603 aa, which promotes the proliferation of multiple myeloma cells via regulating exon skipping of S-phase kinase associated protein 2 and stabilizing c-Myc protein [39]. The gene discussed is HNRNPU; the disease is plasma cell myeloma.