CDK5R1 and neurodegenerative disease: However, unlike neurodegenerative diseases, where CDK5 deregulation is predominantly believed to be due to p25 formation, in cancers, it is mainly due to CDK5 and/or p35 (and sometimes p39) overexpression/amplification, although in medullary thyroid carcinoma (MTC), high p25 levels have been reported [34] (Table 1).