Abnormalities of FGFR1, including amplification [7, 8], chromosome rearrangement [9] or gene fusion [10, 11], point mutation [12], and epigenetic deregulation [13, 14] have been reported in a variety of carcinomas, such as lung cancer, alveolar rhabdomyosarcoma, lymphoid neoplasms, extra ventricular neurocytoma, glioma, rosette-forming glioneuronal tumor, and head and neck squamous cell carcinoma. Here, FGFR1 is linked to head and neck squamous cell carcinoma.