In head and neck squamous cell carcinomas, FGFR1 gene hyper-methylation was found at 18 of 42 CpG sites and hypo-methylation at 16 of 42 CpG sites [49], and FGFR1 demethylation was associated with acquired cetuximab resistance [14]. Here, FGFR1 is linked to head and neck squamous cell carcinoma.