In the present study, we discovered circFGFR1int2, a novel circRNA derived from intron 2 of FGFR1, was up-regulated in PCa and promoted PCa progression by facilitating FGFR1 transcription through recruiting transcription activators P65/FUS that interacted with FGFR1 promoter. The gene discussed is FUS; the disease is posterior cortical atrophy.