Melanoma treated with CSPG4-CAR.CIK showed a significantly lower metabolic rate compared to tumors treated with unmodified CIK (1.8 × 108 ± 9.2 × 107 and 1.1 × 109 ± 3.5 × 108 photons/sec, respectively, p < 0.0001) (Fig. 5C). The gene discussed is CSPG4; the disease is melanoma.