The most highly downregulated genes in GPR81 KD cells included Sperm protein associated with the nucleus X-chromosome-A2 (SPANXA2) [50], Transmembrane O-Mannosyltransferase Targeting Cadherins-1 (TMTC1) [51], and LIM and calponin homology domain 1 (LIMCH1), an actin-regulatory protein implicated in cervical cancer development [52] (Fig. 4f). Here, MSH6 is linked to cervical cancer.