The integrated bioinformatics analysis approach revealed 11 hub-proteins (MAPK1, MAPK3, TP53, JUN, STAT3, SRC, RELA, AKT1, MAPK14, HSP90AA1 and DLG4), 5 TFs (FOXC1, GATA2, YY1, TFAP2A and SREBF1) and 6 miRNAs (miR-375, miR-17-5, miR-17-5p, miR-106a-5p, miR-125b-5p, and miR-125a-5p) associated with delirium. This evidence concerns the gene TFAP2A and delirium.