It is of the utmost importance to mention that NAP1L2 knockdown and SIRT3 activation also elevated the protein expression of BCAT2 and PP2Cm in HG-exposed CF, indicating that periostin might decrease BCAA catabolism in DCM by regulating the NAP1L2/SIRT3 pathway. This evidence concerns the gene SIRT3 and familial dilated cardiomyopathy.