Similarly, For pancreatic neuroendocrine tumors (Pan-NETs), the ESMO guidelines state that patients with highly functional Pan-NETs with a high tumor burden may benefit from tumor debulking surgery (e.g., insulinomas, vasoactive intestinal peptide (VIP)omas), and surgery is typically recommended for this indication. The gene discussed is VIP; the disease is pancreatic neuroendocrine tumor.