On the other hand, it was shown that blockage of IFN-γ receptor in Ovarian cancer cells resulted in reduction of PD-L1 expression and induction of CD8+ T-cell infiltration in to the site of tumor which indicating that IFN-γ-induced PD-L1 expression may play decisive role in cancer cell immune escape29. The gene discussed is CD8A; the disease is ovarian carcinoma.