IFNG and osteosarcoma: Accordingly, patients with recurrent osteosarcoma tumors (0.7 ± 0.05) expressed a higher level of IFN-γ compared to their non-recurrent counterparts (0.43 ± 0.02) (P < 0.0001); while the difference between patients with recurrent and non-recurrent Ewing sarcoma tumors was not statistically significant (Fig. 4F).