CD274 and neoplasm: Based on the data, the expression level of PD-L1 was significantly increased in bone tumors compared to non-cancerous tumor margin (P < 0.0001) with the mean and standard error of the mean (SEM) of 0.69 ± 0.04 for tumor tissues and 0.09 ± 0.01 for tumor margins (Fig. 1A).