TLR4 and Immunodeficiency: All genes from the classic signalling pathways; Janus kinase (JAK)/signal transducer and activator of transcription (STAT), immune deficiency (Imd), Toll and Jun N-terminal kinase (JNK)—were identified with one-to-one orthologs for An. darlingi. Cascade modulators (e.g., serine proteases) accounted for 25.64% of identified immune response genes.