Adenosine triphosphatase H+ transporting accessory protein 2 (ATP6AP2) attenuation triggers intracellular acidification and lysosomal pH alkalinized in in senescent breast cancer cells induced by doxorubicin and abemaciclib, resulting in immune profile alterations through the reprogramming of senescence-associated secretory phenotype. This evidence concerns the gene ATP6AP2 and breast cancer.