Adenosine triphosphatase H+ transporting accessory protein 2 (ATP6AP2) attenuation triggers intracellular acidification and lysosomal pH alkalinized in in senescent breast cancer cells induced by doxorubicin and abemaciclib, resulting in immune profile alterations through the reprogramming of senescence-associated secretory phenotype. The gene discussed is ATP6AP2; the disease is breast carcinoma.