In the acute phase of the infection, the evaluation of the ratio (5/18) of the C1-INH-HAE patients with attacks during the infection was influenced by the facts that 4/18 (22%) patients have never had HAE attack before; 2/18 (11%) patients did not have an attack for 2 years; 1–1/18 (6%) patients did not have an attack for 8 and 15 years. Here, SERPING1 is linked to infection.