The received results are influenced by the fact that 12 of the 18 patients (67%) did not have any comorbidities besides C1-INH-HAE, 4 patients (22%) were treated with hypertension, including the patient who was hospitalized, 1 (5.6%) patient was treated with hyperthyroidism and 1 (5.6%) with anxiety disorders. This evidence concerns the gene SERPING1 and Hypertension.