It has been shown that the tumor-derived cytokine CCL20 upregulates IDO expression, and IDO also inhibits CD8+ T cell responses and induces tumor immune evasion, so it is highly likely that the strong rise of CCL20 in PBK overexpression inhibits CD8+ T cells via IDO1 (Fig. 7G). The gene discussed is IDO1; the disease is neoplasm.