According to the results of the aforementioned study, we discovered that MAT1A and NR1I3 were not substantially connected with prognosis in the TCGA-LIHC cohort, indicating that HSPA1A and PPARGC1A may be crucial in the development of B[a]P-NASH-HCC. Here, PPARGC1A is linked to metabolic dysfunction-associated steatohepatitis.