But according to our previous study, inhibition of BRD4 reduces erastin-ferrop susceptibility of tumor cells via blocking the expression of nuclear transcription mitochondrial lipid metabolism genes including hydroxyacyl-CoA dehydrogenase (HADH), acyl-CoA synthetase long-chain family member 1 (ACSL1) and acetyl-CoA acyltransferase 2 (ACAA2) [21]. Here, ACSL1 is linked to neoplasm.