ACSL3 and cancer: Despite the proposal of an effective method to promote ferroptosis tolerance through increased intake of exogenous MUFAs depending on ACSL3, other studies have suggested a link between ACSL3 deficiency and ATP consumption in cancer cells, which may hinder the synthesis of PUFAs and be disadvantageous to ferroptosis, as the energy system is as vital as the enzymatic system in determining the PUFAs synthesis and ferroptosis.