In assessments of the global CD4 + T cell responses with respect to their distribution across the aligned clusters defined by DISCOV-R, we observed a higher proportion of Th2-like cells (AC1) and a lower proportion of Th17 cells (AC2) and Th17.1 cells (AC4) in Early RA participants compared to anti-CCP3(−) (Supplementary Fig. 5). The gene discussed is AGBL3; the disease is rheumatoid arthritis.