In tumor tissue, glucose transporter (GLUT) 1, 4, 7 (Glut1, Glut4, and Glut7), phosphoglucomutase 1, 2 (Pgm1, Pgm2), hexokinase 1, 2, 3 (Hk1, Hk2, Hk3), pyruvate kinase M1/2 (Pkm), and phosphofructokinases (Pfkp, Pfkl) were significantly inhibited (Fig. 4c), supporting the reduction of glucose metabolism in tumor tissues. This evidence concerns the gene PKM and neoplasm.