This phenotypic switch significantly enhanced NK-cell mediated lysis of both GD2+ and GD2– target neuroblastoma cells in vitro.78 NK cells represent a particularly attractive target in neuroblastoma due to their capacity for MHC-I independent target cell killing, using alternative interactions such as TRAIL to target tumour cells with cytolytic granules.81 The gene discussed is TNFSF10; the disease is neuroblastoma.