Also, the prevalence of somatic mutations of NRGs in AML was not widespread, and the top-eight genes with altered expression were FLT3 (8%), IDH2 (7%), IDH1 (5%), AXL (1%), MYC (1%), DNMT1 (1%), ALK (1%), and SLC39A7 (1%) (Figure 1C). Here, IDH2 is linked to acute myeloid leukemia.