TP53 and neoplasm: However, at multivariable analysis including clinical and pathological parameters, only ENSAT tumour stage and resection status remained significantly associated with PFS (P= 0.004, HR 1.60, 95%CI 1.16–2.21; and P= 0.036, HR 1.48, 95% CI 1.03–2.14 by Cox regression analysis), while ENSAT tumour stage and combined TP53 status-PLK1 expression showed only a trend (P= 0.087, HR 1.33, 95% CI 0.96–1.85; and P= 0.170, HR 1.30, 95% CI 0.89–1.88).