We showed that infants exposed to PCOS with hirsutism had decreased DNAm at cg02372539 near the DACT2 gene on chromosome 6, as well as increased DNAm at cg08471713 near the MEOX1 gene on chromosome and cg17897916 on chromosome 15 after adjustment for potential confounders, including pre-pregnancy BMI. This evidence concerns the gene DACT2 and polycystic ovary syndrome.