CHEK2 and Lynch syndrome: There were statistically significant increased frequencies of PGVs in this study in BRCA2, ATM, CHEK2, BRCA1, and Lynch syndrome–associated MMR genes compared with the frequencies seen in the referenced control cohort of unaffected individuals undergoing proactive genetic screening (P < 10−5) of 6.8-, 3.6-, 8.8-, 3.6-, and 2.7-fold, respectively.