Furthermore, the increasing knowledge of the underlying mechanisms that produce mucosal inflammation in CRSwNP (the mucosal concept) [9•] and the description of several biomarkers, such as immunoglobulin E (IgE), eosinophilic cationic protein (ECP), or interleukins (IL) 4, 5, and 13, have led the description of subjacent inflammatory endotypes and consequent phenotypes and allow the application of the precision medicine paradigm in the management of CRSwNP patients [10, 11]. The gene discussed is IGHE; the disease is chronic rhinosinusitis with nasal polyps.