Artur et al. (Rangel-Filho et al. 2013) studied hypertension-associated nephropathy rats with Rab38 knockout and found that the reason why the rats have elevated UACR level and impaired renal function may be that the dysfunction of renal tubular reabsorption caused by Rab38 knockout, while glomerular injury has little effect in this process. This evidence concerns the gene RAB38 and Nephropathy.