Taken together, Tan is superior to paricalcitol in ameliorating tubulointerstitial fibrosis in DN rats, which can improve the symptoms of “three more and one less,” reduce FBG level, improve renal index, BUN/Scr, and UACR, reduce histopathological damage of kidney, and improve the expression of fibrosis-related proteins in kidney tissue by regulating VDR/Wnt/β-catenin pathway. The gene discussed is VDR; the disease is liver dysplastic nodule.