RYR2 and cardiovascular disorder: To discover new multifunctional agents for the treatmentof cardiovasculardiseases, we designed and synthesized a series of compounds with acyclopropyl alcohol moiety and evaluated them in biochemical assays.Biological screening identified derivatives with dual activity: preventingCa2+ leak through ryanodine receptor 2 (RyR2) and enhancingcardiac sarco-endoplasmic reticulum (SR) Ca2+ load by activationof Ca2+-dependent ATPase 2a (SERCA2a).