ZNF85 and Sepsis: In this report, we show that hPF4 dampens the thrombotic and endothelial cell–activating effects of cfDNA fragments derived from HMW DNA, demonstrating that hPF4 may also exert protective effects in sepsis by aggregating circulating nucleic acids that originate not only from NETs, but from necrosis, apoptosis, and increased red cell turnover.