After stimulation with TNF-α (1.0 ng/mL), quantitative real-time PCR of sarcoma osteogenic (SaOS-2) cells revealed that 6A-8R (1.5 and 3.0 mg/mL) inhibited the expression of the sclerosteosis gene (SOST) (Figure 7A). The gene discussed is TNF; the disease is sarcoma.