In line with our observations, 2 recent studies in preclinical models of DIPG (with the bifunctional LSD1/HDAC inhibitor Corin) and GBM (with the small molecule MS-275) demonstrated that HDAC inhibition induces the expression of genes related to neuronal differentiation in vitro and in vivo (56, 57). Here, HDAC9 is linked to glioblastoma.