In agreement with our findings of microglial activation in symptomatic hAβ-KI mice, among the tested major proinflammatory cytokines, including IL1, IL6, and TNFA, that participate in AD inflammatory brain damage (74), we found remarkably increased gene expression of TNFA in aMCI brains (Supplemental Figure 16, A–C). This evidence concerns the gene TNF and Alzheimer disease.