MAPT and tauopathy: Next, to exclude the impact of tauopathy on synaptic mitochondrial function in hAβ-KI mice, we performed immunoblotting (IB) using brain extracts from aged hAβ-KI and nonTg mice and observed no discernible difference regarding the amount of total tau or phosphorylated tau at S396/S404 between the 2 groups of mice (Supplemental Figure 11).