Four mutation-relevant clusters were also identified by using the following mutational signatures from the Catalog of Somatic Mutations in Cancer (https://cancer.sanger.ac.uk/cosmic): APOBEC (n = 11; 10%), homologous recombination deficiency (HRD; n = 34; 29%), clock-like (n = 39; 34%), and mixed (n = 31; 27%) (Supplemental Figure 4B). This evidence concerns the gene CLOCK and cancer.