Furthermore, H&E staining demonstrated a high level of both stromal tumor-infiltrating lymphocytes (TILs; C4 vs. C1, P = 0.0353; vs. C2, P = 0.0006; vs. C3, P = 0.0014) and intratumor TILs (C4 vs. C1, P = 0.0008; vs. C2, P < 0.0001; vs. C3, P = 0.0329) in C4 (Figure 1F), and a CIBERSORT analysis (14) illustrated that several immune-activated cells (15), such as CD8+ T cells (C4 vs. C1, P < 0.0001; vs. C2, P < 0.0001; vs. C3, P < 0.0001) and activated NK cells (C4 vs. C1, P = 0.0012; vs. C2, P = 0.0058; vs. C3, P = 0.0001), were relatively enriched in C4 (Figure 1G). Here, CD8A is linked to neoplasm.