The results from TCGA‐HNSCC showed that the high expression group of TTC7B exhibited increased expressions of ferroptosis inducers, including TFRC, NCOA4, ATG5, VDAC2, ALOX15, TP53, ACSL1, ACSL4, ACSL6, FTL, LPCAT3, and MAP1LC3B (p < 0.05). This evidence concerns the gene ACSL4 and head and neck squamous cell carcinoma.