Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by the formation and deposition of cerebral amyloid β (Aβ) plaques that have abundant downstream effects such as increased hyperphosphorylation of tau, neuroinflammatory events, which ultimately results in neurodegeneration and cognitive decline.[1, 2, 3, 4] Although this amyloid cascade has been identified as a persuasive hypothesis explaining the etiology of AD and research has been ongoing for decades to develop potent therapeutics against it, the success rates are limited primarily due to its complexity. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.