PRKN and Parkinson disease: Moreover, comparing PD versus CN, plasma PINK1 level discriminated abnormal versus normal a‐synuclein status with an AUC of 0.775 in a‐syn (+) versus 0.595 in a‐syn (−) subjects (Figure 5F,G), which was mild higher than the AUCs for plasma levels of Parkin (0.694 vs. 0.567) and PGAM5 (0.751 vs. 0.773), indicating PINK1 showed higher diagnostic accuracy than established plasma Parkin and PGAM5 biomarkers in A‐syn (+) subjects.