The AUC was 0.883 (95% CI: 0.831–0.934) when combined with analysis of MAPs (PINK1, PGAM5, and Parkin), which was like the AUCs for Bio‐Top3 (a‐syn oligomer, PINK1 plus Parkin) and MAPs plus a‐syn oligomer of 0.899 (95% CI: 0.85–0.947), indicating the MAPs may be promising as a compound biomarker to differentiate PD from HC. This evidence concerns the gene C3orf62 and Parkinson disease.