For HD issues, damaged mitochondrial and proteostasis alterations, especially in the autophagic/endosomal system, including the mutation of Autophagy Related Protein 7 (ATG7) and impairment of GAPDH‐mediated mitophagy by mutant Htt, are related to the pathogenesis of HD.39 The gene discussed is HTT; the disease is Huntington disease.