Several genes linked to ALS and FTD encode proteins involved in mitophagy, including optineurin (OPTN), TANK‐binding kinase 1 (TBK1), p62, and receptor‐interacting protein kinase 1 (PIPK1) et al,10 but how mutation of these genes contributes to the pathology is not fully understood. The gene discussed is OPTN; the disease is amyotrophic lateral sclerosis.