CD4 and glioblastoma: The primary glioblastoma of patient Fam011-III.1/M1 showed an increased immune infiltrate compared to a POLE WT glioblastoma, which was composed mainly of PD-1-positive CD3+ T lymphocytes co-expressing CD4, and CD68+ macrophages (Fig. 4a, c, e, Additional file 1: Table S3).