POLD1 and brain neoplasm: As one of the two POLD1 germline variants was detected in a patient with an oligodendroglioma (Fig. 1j), a rare brain tumor characterized by a 1p/19q codeletion [2] comprising the POLD1 locus at 19q13.33, we hypothesized that POLD1 germline variants may be particularly frequent in patients with oligodendrogliomas.