Taken together, in eight of nine (89%) POLE-mutated primary glioblastomas or spinal metastases, including three tumors harboring variants classified as likely pathogenic (Additional file 1: Table S4), the density of total CD3+ T lymphocytes and/or CD4+ or CD8+ subsets was increased compared to controls with WT POLE (Additional file 1: Table S3). The gene discussed is CD4; the disease is glioblastoma.