POLE and central nervous system cancer: Taken together, seven different rare POLE and two different rare POLD1 variants, heterozygous and predicted to be deleterious, were detected in WES datasets of leukocyte DNA of a total of 11 glioma patients from 10 of 61 (16%) tumor families, including the glioma patients from family Fam011 (Fig. 1a-j, Additional file 2: Fig. S1, Table 1).