POLE and Familial prostate cancer: In the 10 families carrying POLE/POLD1 variants, other tumors were colorectal cancer (4/10, 40%), breast cancer (2/10, 20%), uterus cancer (1/10, 10%), prostate cancer (1/10, 10%), and small cell lung cancer (1/10, 10%) (Fig. 1; Table 2).