The density of total CD3+ T lymphocytes and/or CD4+ or CD8+ subsets was increased in six of seven (86%) POLE-mutated primary glioblastomas, and that of CD68+ macrophages in three of seven (43%) POLE-mutated primary glioblastomas compared to the mean density in five POLE WT glioblastomas (Fig. 4c, Additional file 1: Table S3). The gene discussed is POLE; the disease is glioblastoma.