Consistent with our finding of enlarged nuclei or multinucleated cells in 6/15 (40%) gliomas from patients with POLE/POLD1 germline variants, multinucleated giant or bizarre cells, features of giant cell glioblastoma, were previously observed in high-grade gliomas harboring somatic POLE variants [33]. Here, POLD1 is linked to giant cell glioblastoma.