Owing to the elevated expression levels of pro-inflammatory cytokines in the PBMCs of PD patients compared to HC [14], and considering that NLRP3 has been proposed as a target gene of miR-30e-5p [26], our subsequent objective was to determine whether the NLRP3 inflammasome is activated in PD patients. This evidence concerns the gene NLRP3 and Parkinson disease.