Indeed, the ROC curve analyses showed that the combination of PBMCs NURR1, miR-30e-5p and NLRP3 enhances the discriminatory accuracy between PD and HC, indicating that the combination of NURR1, miR-30e-5p and NLRP3 expression in PBMCs could be utilized as collective biomarkers for PD diagnosis. Here, NR4A2 is linked to Parkinson disease.