Furthermore, the level of miR-30e-5p in PBMCs showed an inverse correlation with both the NLRP3 level (Rho = − 0.455, p < 0.01) and plasma IL-1β level (Rho = − 0.385, p < 0.01) in PD (Fig. 3A). Here, NLRP3 is linked to Parkinson disease.