AGT and neoplasm: In order to apply 3PND for determining an optimal dose of \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\text {O}^{6}$$\end{document}O6-BG, we perform a transformation on the actual values of tumor AGT activity, yielding “60 - Tumor AGT activity,” which will be used as the continuous response in 3PND.