In the following, we employ 3PND and EWOC to determine the optimal dose of \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\text {O}^{6}$$\end{document}O6-BG, resulting in undetectable tumor AGT levels (< 5 fmol/mg), as similarly researched by [35]. Here, AGT is linked to neoplasm.