Reduced TSPO signal was found in Braak II (η2 = 0.31; F = 5.41; P = 0.04) and III (η2 = 0.29; F = 4.95; P = 0.046) regions of interest between TREM2 p.R47H carriers and mild cognitive impairment participants, which remained significant after PVC application (Braak II: P = 0.03; Braak III: P = 0.03). Here, TSPO is linked to Cognitive impairment.