However, within Braak II (β = − 0.03 ± 0.02; P = 0.08), Braak III (β = − 0.02 ± 0.01; P = 0.08), Braak IV (β = − 0.02 ± 0.01; P = 0.06) there were trends to suggest that influenza vaccine lowered the TSPO signal in TREM2 p.R47H carriers compared to mild cognitive impairment participants. The gene discussed is TSPO; the disease is Cognitive impairment.