MAPT and Cognitive impairment: TREM2 p.R47H carriers did however have higher tau PET signal in Braak VI than mild cognitive impairment participants (η2 = 0.28; F = 5.0; P = 0.04), although it should be noted that uptake values overall were low in this region in all participants, which is to be expected in the early-stage disease period we were focused on.