Importantly, the analysis of DEGs revealed an elevated level of HTR1B in the prefrontal cortex (PFC) (BA46) of individuals with schizophrenia compared to healthy controls (p = 0.034) (Fig. 1D), while the expression of HTR2A was significantly decreased (p = 0.005) (Additional file 1: Fig. S1A). Here, HTR1B is linked to schizophrenia.