Strikingly, plasma HTR1B concentration also correlated significantly with plasma 5-HT, Arc, and ALKBH5 concentration in schizophrenia patients (r = − 0.6 in 5-HT, r = 0.6 in Arc, r = 0.7 in ALKBH5, Fig. 2O–Q), indicating that HTR1B was associated with m6A modification in schizophrenia. This evidence concerns the gene ALKBH5 and schizophrenia.