Notably, data from our lab has confirmed that ERVWE1 contributes to the occurrence and progression of schizophrenia by increasing the expression of schizophrenia-associated genes [35], activating ion channels [18], modulating mitochondrial respiratory chain function [36], impairing synaptic function and spine development [37, 38], and inducing neuroinflammatory abnormalities [39–42]. Here, ERVW-1 is linked to schizophrenia.