However, the exact location within MDS progenitor cells where this TNFα-induced apoptotic process occurs remains unknown, whether it takes place in the early progenitor cells (CD34 +) or in the differentiated myeloid progenitor cells (CD33 +) and megakaryocyte progenitor cells (CD41+) [10, 11]. This evidence concerns the gene ITGA2B and myelodysplastic syndrome.