RAI1 and Smith-Magenis syndrome: For example, Smith-Magenis Syndrome (OMIM: 182290) and Potocki-Lupski syndrome (OMIM: 610883) involve a reciprocal microdeletion and microduplication, respectively, at the locus 17p11.2 that affects the dosage-sensitive gene Retinoic acid-induced 1 (RAI1) (MIM: 607642)34,35.