IFI6 and neoplasm: Five genes were enriched in this motif, which were (in order): AATF, FGL2, FOXO3, IFI6 and LEFTY1.Studies have shown that the apoptosis-antagonising transcription factor (AATF) acts through the p38/MK2/AATF signalling pathway as a critical repressor of p53-driven apoptosis in tumour cells, implicating this signalling cascade as a novel target for chemotherapy-sensitising therapeutic efforts42.