FN1 and colorectal carcinoma: On the protein level, SARIFA-positive CRCs exhibited pronounced upregulation of Fibronectin and Annexin A, hinting on the one hand again at the key role of extracellular matrix organization with regards to SARIFA-status [56], and on the other hand on immunomodulatory changes within SARIFA-positive CRCs [57], which supports our previous findings of an altered immune response in SARIFA-positive CRC patients [9].