Likewise, at least 10 other human solid tumors are deficient in KAI1/CD82 metastasis suppressor gene expression: hepatocellular carcinoma, clear cell renal cell carcinoma, melanoma, osteosarcoma, pancreatic carcinoma, prostate cancer, ovarian cancer, bladder carcinoma, cervical carcinoma, and thyroid cancer6–9. The gene discussed is CD82; the disease is osteosarcoma.