We identified 161 high-confidence gene fusions (Supplementary Data 10; “Methods”), including disease-defining fusions such as reciprocal EWSR1-ATF1 in a clear cell sarcoma (patient 529) and BCOR-CCNB3 in a Ewing-like sarcoma (patient 2197). The gene discussed is EWSR1; the disease is clear cell sarcoma.